Basic & Translational Research

Oral replacement therapy of the retinoid intermediate that fails to form in some types of Leber congenital amaurosis shows significant promise in an early-phase clinical trial

Might you soon take a skin cell from a patient with retinitis pigmentosa, roll it back to a pluripotent state, culture it to become retinal cells and trial gene therapy on it in vitro?

The body’s own regulatory T-lymphocytes, known as Tregs, can be taught to douse inflammation.

Sitting Down With Alice McPherson,founder of the Retina Research Foundation

Subcutaneously-administrated IL-18 works well to reverse choroidal neovascularization (in mice).

The new method to produce stem cells has run into difficulties in the form of image irregularities and the failure of other labs to reproduce the findings.

Can you envisage a future in which deploying a tiny cell-spraying device during vitreoretinal surgery reverses years of retinal cell death? Keith Martin can.

An unexpected and simple advance has made stem cell production much easier and safer. Do STAP stem cells bring the treatment, even cure, of ocular disease a lot closer?

The EMA approved the first gene therapy agent in 2012 – for lipoprotein lipase deficiency. Might gene therapies for ophthalmic disease reach the wards any time soon?

Transplanting pancreatic Islets of Langerhans into the ocular anterior chamber of the eye allows researchers to effectively monitor ?-cell function.